Human embryonic stem cells; Induced pluripotent stem cells; Neural stem cells; Disease models; Drug discovery; Stroke; Neurological disorders; Regenerative medicine
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  • Chief Investigator & Principal Fellow, Synthetic Biosystems Laboratory, ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute/AIIM Facility, Innovation Campus, University of Wollongong
  • Associate Professor & Principal Fellow, Illawarra Health and Medical Research Institute, University of Wollongong
  • Associate Professor & Principal Fellow (Honorary), Department of Surgery – St Vincent’s Hospital, The University of Melbourne

Websites: http://ipri.uow.edu.au/people/UOW158774.html; electromaterials.edu.au

Research interests

Jeremy’s research involves human pluripotent and neural stem cells for disease modelling and ex vivo tissue engineering, and incorporates novel biomaterials for improved cell culture and differentiation, early phase drug discovery, and regenerative medicine. Jeremy has a special interest in modelling disorders of the human central nervous system (eg. major mental disorders [MMDs] such as schizophrenia) to study disease susceptibility gene dysfunction and environmental risk factors.  By investigating gene-environment interaction Jeremy’s laboratory aims to identify novel biomarkers for improved diagnostics and therapeutics, and provide a new framework for understanding the etiopathology of MMDs. Jeremy’s approach is complimentary to in vivo experimentation and other conventional research methods, and fits well with the broadly accepted notion that a better understanding of the biological mechanisms underlying MMDs must be forthcoming before new diagnostic tools and better treatments can be developed.

Publications

1. Stewart E, Kobayashi NR, Higgins M, Quigley A, Moulton S, Kapsa R, Wallace G, Crook JM (2014) Electrical Stimulation Using Conductive Polymer Polypyrrol Promotes Neuronal Differentiation of Human Neural Stem Cells: A Biocompatible Platform for Translational Neural Tissue Engineering. Tissue Engineering Part C - Methods. In Press.

2. Felimban R, Ye K, Di Bella C, Crook JM, Traianedes K, Moulton S, Wallace G, Kapsa R, Quigley A, Choong PFM, Myers D (2014) Differentiation of stem cells derived from human infrapatellar fat pad for cartilage engineering: Characterisation of cells undergoing chondrogenesis. Tissue Engineering: Part A. Epub ahead of print. DOI: 10.1089/ten.2013.0657.

3. Crook JM and Stacey G (2014) Setting Quality Standards for Stem Cell Banking, Research and Translation: The International Stem Cell Banking Initiative. In Stem Cell Biology and Regenerative Medicine: Stem Cell Banking; ed Turksen K. Springer. pp3-10.

4. Stacey G, Crook JM, Hei D, Ludwig T (2013) Banking human induced pluripotent stem cells: lessons learned from embryonic stem cells? Cell Stem Cell. 13(4):385-388.

5. Amps et al. (2011) Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nature Biotech. 29(12):1132-1144.

6. Luong MX, Auerbach J, Crook JM, Daheron L, Hei D, Lomax G, Loring JF, Ludwig T, Schlaeger TM, Smith KP, Stacey G, Xu RH, Zeng F (2011) A call for standardized naming and reporting of human ES and iPS cell lines. Cell Stem Cell. 8(4):357-359.

7. Tomaskovic-Crook E & Crook JM (2011) Human Embryonic Stem Cell Therapies for Neurodegenerative Diseases. CNS Neurol Disord Drug Targets. 10(4):440-448.

8. Crook JM (2011) Differentiation of pluripotent stem cells: an overview. In: Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual. John Wiley & Sons, Inc. pp289-296.

9. Kobayashi NR, Sui L, Tan PS, Lim EK, Chan J, Choolani M & Crook JM (2010) Modelling disrupted-in-schizophrenia 1 loss of function in human neural progenitor cells: tools for molecular studies of human neurodevelopment and neuropsychiatric disorders. Nature Molec Psychiatry. 15:672–675.

10. Crook JM (2010) Human iPS Cells: Science and Ethics. The Open Stem Cell Journal. 2:1. Editorial. Hot Topic / Special Issue.

11. Phillips BW, Horn R, Tan SL, Rust WL, Tan TT & Crook JM (2008) Attachment and growth of human embryonic stem cells on microcarriers. J of Biotechnol, 138(1-2):24-32.

12. Crook JM, Peura T, Kravets L, Bosman A, Buzzard JJ, Horne R, Hentze H, Dunn NR, Zweigerdt R, Chua F, Upshall A, Colman A (2007) The generation of six clinical-grade human embryonic stem cell lines. Cell Stem Cell, 1:490-494.

13. Crook JM, Horne R & Colman A (2006) Standard Culture of Human Embryonic Stem Cells, In Human Embryonic Stem Cells: The Practical Handbook; ed. Sullivan S, Cowan C & Eggan K, John Wiley & Sons, Ltd. pp53-79.


14. Bibikova M, Chudin E, Wu B, Zhou L, Garcia EW, Liu Y, Shin S, Plaia TW, Auerbach JM, Arking DE, Gonzalez R, Crook J, Davidson B, Schulz TC, Robins A, Khanna A, Sartipy P, Hyllner J, Vanguri P, Savant-Bhonsale S, Smith AK, Chakravarti A, Maitra A, Rao M, Barker DL, Loring JF & Fan JB (2006) Human Embryonic Stem Cells Have a Unique Epigenetic Signature. Genome Research. 16(9):1075-1083.

15. Crook JM, Dunn NR & Colman A (2006) Repressed by a NuRD. Nature Cell Biol. 8(3):212-214.

16. Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G, Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui S, Carpenter M, Gazdar AF, Rao M, & Chakravarti A (2005) Genomic alterations in cultured human embryonic stem cells. Nature Genetics. 37(10):1099-103.

17. Buzzard JJ, Gough NM, Crook JM, & Colman A (2004) Karyotype of human ES cells during extended culture. Nature Biotech. 22(4):381-382.
 

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