iPS cells, adult stem cells, kidney repair, kidney disease, chronic inflammation, clinical drug screening
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  • Group Leader, Kidney Stem Cell and Regeneration Laboratory
  • Director, MBio Graduate School, Monash University

Research interests

The Kidney Regeneration and Stem Cell Laboratory at MISCL, Monash University focuses on the development of stem cell-based therapies and/or growth factors that may repair damaged kidney tissues and reverse the development of scarring, thereby reducing the need for kidney dialysis or organ transplantation.

Ongoing projects include:

  1. Pluripotent stem cells from patients with kidney disease
    We have recently derived iPS cells from human kidneys (Song et al, JASN 2011) and are currently generating iPS cells from patients with genetic kidney disease including polycystic kidney disease and Alports Syndrome. These iPS lines that maintain the disease genotype and phenotype, will be used for disease modeling and screening new and existing drug compounds that will offer alternatives to the limited framework of prevailing clinical options. The long-term objective is to developiPS cells as a method to produce differentiated human kidney cell types in sufficient quantities that can be used in high-throughput in vitro toxicity screens and ultimately cell therapies for patients with chronic kidney disease.
  2. Immune modulation and bone marrow-derived cells in kidney repair
    This research is focused on the development of strategies to promote kidney ‘self-repair’ and the monocyte/macrophage phenotypesthat are important in this process. As we have recently reported (Alikhan et al. Am J Pathol 2011)macrophages are critical regulators of tissue homeostasis, providing an essential role during organogenesis and adult tissue repair. We are interested in the processes underlying inflammation and repair that are driven by macrophages/monocytes. Understanding the heterogeneous nature of myeloid cells and the supporting stromal cells during inflammation and tissue repair provides the means to identify, recruit and polarise desirable populations, and raises new and exciting therapeutic possibilities to attenuate or conceivably reverse progressive renal disease.

Publications

  1. Li J, Deane JA, Campanale NV, Bertram JF, and Ricardo S.D. Modulation of the contribution of bone marrow-derived cells to renal repair and the development of interstitial fibrosis. Stem Cells 2007:25(3):697-706.
  2. Ricardo S.D., H van Goor. Eddy A.A. Macrophage diversity in renal injury and repair. Journal of Clinical Investigation 2008:118(11); 3522-3530.
  3. Verghese E, Ricardo SD, Weindenfeld R, Liang R, Hill P, Langham R, Deane JA. Renal Primary Cilia Lengthen after Acute Tubular Necrosis. Journal of the American Society of Nephrology 2009; 20(10): 2147-2153. Featured on cover.
  4. Zhuang J, Deane JA, Yang RB, Li J, Ricardo S.D. Scube-1, a novel developmental gene involved in renal regeneration and repair. Nephrology, Dialysis and Transplantation 2010; 25: 1421 – 1428.
  5. Williams TM, Little MH, Ricardo SD. Invited review: Macrophages in Renal Development, Injury and Repair. Seminars in Nephrology 2010; 30:255-267.
  6. Lin A, Kolle G, Grimmond S, Zhou G, Doust E, Little MH, Aronow B, Ricardo S, Pera MF, Bertram JF, Laslett A. Subfractionation of differentiating hES cell populations allows the isolation of a mesodermal population enriched for intermediate mesoderm and putative renal progenitors. Stem Cells and Development, 2010 19(10): 1637-1648.
  7. Alikhan M, Jones CV, Williams TM, Beckhouse AG, Fletcher AL. Kett MM, Sakkal S, Samuel CS, Ramsay RG, Deane JA, Wells CA, Little MH, Hume DA, Ricardo SD. CSF-1 promotes kidney development and postnatal repair via alteration of a macrophage response. American Journal Pathology, 179 (3): 1243-1256, 2011.
  8. Song B, Niclis J, Alikhan M, Sakkal S, Sylvain A, Kerr PG, Laslett AL, Bernard CA and Ricardo SD. Generation of induced pluripotent stem cells from human mesangial cells. Journal of the American Society of Nephrology 22(7):1213-1220, 2011. Featured in editorial highlight; cover image.
  9. Wise AF and Ricardo SD. Invited Review: Mesenchymal Stem Cells in Kidney Inflammation and Repair. (In Press) Nephrology, 2011.
  10. Song B, Sun G, Herszfeld D, Sylvain S, Campanale N, Hirst CE, Caine S, Parkington H, Tonta MA, Coleman HA, Short M, Ricardo SD, Reubinoff B, and Bernard CCA. Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis. Stem Cell Research (In Press) 2011.
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