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  • Group Leader, Molecular Genetics Research Group, The University of Barcelona
  • Honorary Senior Research Fellow, University of Sydney

Research interests

  1. Reprogramming cord blood and patient fibroblasts to iPS cells
  2. Cell cycle as a barrier to reprogramming
  3. Modeling human disease, neuronal and Cardiac disease
  4. Advancing the technology to make iPS cells
  5. Application of iPS cells: Towards the clinic.


  1. McLenachan S, Menchón C, Raya A, Consiglio A, Edel MJ. Cyclin a(1) is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells. Stem Cells Dev. 2012 Oct 10;21(15):2891-9. doi: 10.1089/scd.2012.0190. Epub 2012 Jun 25.
  2. Menendez S, Camus S, Herreria A, Paramonov I, Morera LB, Collado M, Pekarik V, Maceda I, Edel M, Consiglio A, Sanchez A, Li H, Serrano M, Belmonte JC. Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency. Aging Cell. 2012 Feb;11(1):41-50. doi: 10.1111/j.1474-9726.2011.00754.x. Epub 2011 Nov 10.
  3. Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua Belmonte JC. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Hum Gene Ther. 2012 Jan;23(1):56-69. Epub 2011 Nov 17.
  4. Edel MJ, Menchon C, Vaquero JM, Izpisua Belmonte JC. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells. Cell Commun Signal. 2011 Apr 11;9(1):8.
  5. Menchón C, Edel MJ, Izpisua Belmonte JC. The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle. 2011 May 1;10(9):1435-47. Epub 2011 May 1.
  6. Edel MJ, Boué S, Menchon C, Sánchez-Danés A, Izpisua Belmonte JC. Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. Cell Cycle. 2010 Sep 1;9(17):3414-22. Epub 2010 Sep 11.
  7. Edel MJ, Menchon C, Menendez S, Consiglio A, Raya A, Izpisua Belmonte JC. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. Genes Dev. 2010 Mar 15;24(6):561-73.


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