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  • Head of the Department of Pharmaceutical Biology (Faculty of Pharmacy and Pharmaceutical Sciences), Exec Member Drug Discovery Biology Theme (MIPS), Monash Institute of Pharmaceutical Science

Research interests

  1. Use of patient-derived iPS cells as models of Parkinson’s, Alzheimers diseases and psychosis
  2. Use of iPS cells to derive mouse models of cells of origin in cancer.

Publications

  1. Pouton CW, Haynes JM (2007). Embryonic stem cells as a source of models for drug discovery. Nat Rev Drug Discov  6(8):605-616. [citations = 57]
  2. Raye WS, Tochon-Danguy N, Pouton CW, Haynes JM (2007). Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function. Eur J Neurosci  25(7):1961-1970.  [citations = 9]
  3. Khaira SK, Pouton CW, Haynes JM (2009). P2X2, P2X4 and P2Y1 receptors elevate intracellular Ca2+ in mouse embryonic stem cell-derived GABAergic neurons. Br J Pharmacol  158(8):1922-1931.
  4. Chen QZ, Jin LY, Cook WD, Mohn D, Lagerqvist EL, Elliott DA, Haynes JM, Boyd N, Stark WJ, Pouton CW, Stanley EG, Elefanty AG (2010). Elastomeric nanocomposites as cell delivery vehicles and cardiac support devices.  Soft Matter  6(19):4715-4726.
  5. Goulburn AL, Alden D, Davis RP, Micallef SJ, Ng ES, Yu QC, Lim SM, Soh CL, Elliott DA, Hatzistavrou T, Bourke J, Watmuff B, Lang RJ, Haynes JM, Pouton CW, Giudice A, Trounson AO, Anderson SA, Stanley EG, Elefanty AG (2011). A Targeted NKX2.1 Hesc Reporter Line Enables Identification of Human Basal Forebrain Derivatives. Stem Cells 29: 462-473.
  6. Lagerqvist EL, Finnin BA, Pouton CW, Haynes JM (2011). Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies. Stem Cell Res 6(1):23-33.
  7. Khaira SK, Nefzger CM, Beh SJ, Pouton CW, Haynes JM (2011) Midbrain and forebrain patterning delivers immunocytochemically and functionally similar populations of neuropeptide Y containing GABAergic neurons. Neurochem Int 59: 413-420
  8. Nefzger CM, Haynes JM, Pouton CW (2011) Directed expression of gata2, mash1, and foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells. Stem Cells 29: 928-939
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