iPS, periodontal disease, periodontal regeneration, mesenchymal induction
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  • Director, Colgate Australian Clinical Dental Research Centre, University of Adelaide

Research interests

The use of periodontal mesenchymal stem cells and induced pluripotent stem cells derived from periodontal tissues for use in periodontal regeneration using tissue engineering principles. Currently, large animal (sheep) and small animal (rat) model for these studies are used in which periodontal defects are surgically created and then the stem cells are surgically implanted into the site on various biocompatible scaffolds. Tissue regeneration is assessed by CT scanning, histological assessment and image analysis. Also under investigation are fundamental aspects of stem cell differentiation and factors which might control such processes.

Publications

  1. Mrozik K, Zilm PS, Bagley CJ, Hack S, Hoffman P, Gronthos S, Bartold PM. Proteomic characterization of mesenchymal stem cell-like populations derived from periodontal ligament, dental pulp and bone marrow: analysis of differentially expressed proteins Stem Cells and Development 19: 1485-1499; 2010.
  2. Menicanin D, Bartold PM, Zannettino ACW, Gronthos S. Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues. Stem Cells & Development 19: 1501-1510; 2010.
  3. Wada N, Bartold PM, Gronthos S. Human Foreskin Fibroblasts Exert Immunomodulatory Properties by a Different Mechanism to Bone Marrow Mesenchymal Stem Cells. Stem Cells and Devlopment 20:647-659; 2011.
  4. Wada N, Wang B, LinN-H, Laslett AL, Gronthos S, Bartold PM. Induced pluripotent stem cell lines derived from human gingival and periodontal ligament fibroblasts Journal of Periodontal Research 46: 438-447; 2011.
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