Epiblast Stem cells; Lineage specification; Endoderm differentiation; Regulation of pluripotency
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  • Head of Embryology Unit and Deputy Director, Children's Medical Research Institute

Research interests

Professor Tam's research focuses on the elucidation of the cellular and molecular mechanisms of body patterning during embryonic development. The embryological studies have revealed a detailed blueprint of development in a series of fate maps that describe the origin of the progenitors of fetal tissues and the organisation of the basic body plan that serves as the blueprint of embryonic development. The knowledge of cell lineage differentiation during early embryogenesis also laid the foundation of the experimental paradigms for directing stem cell differentiation for the application of cell based therapy in regenerative medicine.

Current work focuses on the characterization of the biological properties of pluripotent stem cells derived from post-implantation mouse embryos and the induced pluripotent stem cells that harbor mutation of genes for signalling activity and transcriptional control of endoderm and mesoderm differentiation.

Publications

  1. Loebel DAF, Studdert JB, Power M, Radziewic T, Jones V, Coultas L, Jackson Y, Rao RS, Steiner K, Fossat N, Robb L and Tam PPL (2011) Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development doi:10.1242/dev.063867
  2. Pera M and Tam P P L (2010) Extrinsic regulation of pluripotent stem cells. Nature 465: 713-720
  3. Fossat N, Jones V, Khoo P-L, Bogani D, Hardy A, Steiner K, Mukhopadhyay M, Westphal H, Nolan PM, Arkell R and Tam PPL (2011)Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo Development 138, 667-676 (doi10.1242/dev052803)
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