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  • Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland

Research interests

The Queensland Centre for Medical Genomics is focused on globally surveying genomic, transcriptomic and epigenomic information using next-generation sequencing and array-based approaches, and then integrating this data to define the underlying molecular networks controlling biological processes (such as cell division and differentiation) and pathological states (pancreatic, ovarian and breast cancer). This systems-wide approach will provide the means to identify key genes driving specific phenotypes and also the chance to model the different layers of control guiding biological states.

Publications

  1. G Kolle, J Shepherd, B Gardiner, KS Kassahn, N Cloonan, D Wood, E Nourbakhsh, DF Taylor, S Wani, HS Chy, Q Zhou, K McKernan, S Kuersten, AL Laslett, SM Grimmond. (2011) Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells. Genome Research (in press)
  2. G.J. Faulkner, Y. Kimura, C.O. Daub, S. Wani, C. Plessy, K.M. Irvine, K. Schroder, N. Cloonan, A.L. Steptoe, T. Lassmann, K. Waki, N. Hornig, T. Arakawa, H. Takahashi, J. Kawai, A.R.R. Forrest, H. Suzuki, Y. Hayashizaki, D.A. Hume, V. Orlando, S.M. Grimmond, and P. Carninci, The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics 41 (2009) 563-571.
  3. N. Cloonan, A.R.R. Forrest, G. Kolle, B.B.A. Gardiner, G.J. Faulkner, M.K. Brown, D.F. Taylor, A.L. Steptoe, S. Wani, G. Bethel, A.J. Robertson, A.C. Perkins, S.J. Bruce, C.C. Lee, S.S. Ranade, H.E. Peckham, J.M. Manning, K.J. McKernan, and S.M. Grimmond, Stem cell transcriptome profiling via massive-scale mRNA sequencing. Nature Methods 5 (2008) 613-619.
  4. P. Carninci, A. Sandelin, B. Lenhard, S. Katayama, K. Shimokawa, J. Ponjavic, C.A.M. Semple, M.S. Taylor, P.G. Engstrom, M.C. Frith, A.R.R. Forrest, W.B. Alkema, S.L. Tan, C. Plessy, R. Kodzius, T. Ravasi, T. Kasukawa, S. Fukuda, M. Kanamori-Katayama, Y. Kitazume, H. Kawaji, C. Kai, M. Nakamura, H. Konno, K. Nakano, S. Mottagui-Tabar, P. Arner, A. Chesi, S. Gustincich, F. Persichetti, H. Suzuki, S.M. Grimmond, C.A. Wells, V. Orlando, C. Wahlestedt, E.T. Liu, M. Harbers, J. Kawai, V.B. Bajic, D.A. Hume, and Y. Hayashizaki, Genome-wide analysis of mammalian promoter architecture and evolution (vol 38, pg 626, 2006). Nature Genetics 39 (2007) 1174-1174.
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